A growth factor can send a repair signal. The question is whether your fibroblasts respond the same way when their surroundings change. SENCE™ gives you hydrogel-coated cultureware. Compare the same fibroblasts on softer and stiffer surfaces, with and without your candidate growth factor. Match ECM type, check attachment and presentation, and keep cell density, medium and exposure time consistent. Measure the early signalling response, then follow repair-associated gene expression and matrix deposition. Count viable cells alongside these readouts, so a larger signal is not simply a larger population. In mouse skin fibroblasts, researchers found stronger BMP-7 signalling on soft StemBond research hydrogels. Their animal repair experiments were separate: the culture surface helped investigate mechanism, rather than serving as a treatment. If the growth factor's effect depends on the surface, test that interaction again before advancing. Use the result to choose a relevant, more complex repair model. Through StemBond's Early Access Program, plan a controlled fibroblast study with the team. Bring your signal, your cells and your decision.